Rasburicase for acute kidney injury.

BACKGROUND Acute kidney injury (AKI) continues to have significant mortality and morbidity and the search is on for any novel therapeutic intervention. CASE CHARACTERISTICS Two cases of AKI with elevated SUA (serum uric acid). INTERVENTION Rasburicase. OUTCOME In Case 1 (late preterm male with AKI) rasburicase resulted in a significant reduction of SUA along with improvement in renal parameters. In Case 2 (6 yrs old boy with multi organ failure), rasburicase failed to provide any significant benefit despite fall in SUA. MESSAGE The effect of rasburicase in AKI needs to be studied.